THE ROLE OF SOCIAL DETERMINANTS OF HEALTH IN THE RISK AND PREVENTION OF GROUP A STREPTOCOCCAL INFECTION, ACUTE RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE: A SYSTEMATIC REVIEW.

BackgroundRheumatic heart disease (RHD) poses a major disease burden among disadvantaged populations globally.It results from acute rheumatic fever (ARF), a complication of Group A Streptococcal (GAS) infection.These conditions are acknowledged as diseases of poverty, however the role of specific social and environmental factors in GAS infection an

The Neanderthal and Denisovan genomes enabled rosaliac ar intense visible facial redness serum the discovery of sequences that differ between modern and archaic humans, the majority of which are noncoding.However, our understanding of the regulatory consequences of these differences remains limited, in part due to the decay of regulatory marks in a

Background.Aim was to elucidate the role of toll-like receptor 9 (TLR9) in cardiac inflammation and septic heart failure in a murine model of polymicrobial sepsis.Methods.Sepsis was induced via colon ascendens stent peritonitis (CASP) in C57BL/6 wild-type (WT) and TLR9-deficient (TLR9-D) mice.Bacterial load in the peritoneal cavity and cardiac expr

Forests form rich biodiversity hubs that act as large reservoirs of natural carbon.The spatial and temporal heterogeneity of these complex habitats of forest floors provides ecological services of immense socio-economic importance.However, these socio-economic ecological hotspots are incessantly exposed to multifarious abiotic, biotic, and anthropo